News
A human T-cell, green, which helps the immune system fight viruses, under attack by H.I.V., in yellow. Neanderthal genes may have protected modern humans from an ancestor to the virus.
A human T-cell, green, which helps the immune system fight viruses, under attack by H.I.V., in yellow. Neanderthal genes may have protected modern humans from an ancestor to the virus.

Guiding inactivity of latent HIV reservoirs

Fred Hutch News Service
A retrovirus has a membrane containing glycoproteins, which are able to bind to a receptor protein on a host cell. There are two strands of RNA within the cell that have three enzymes: protease, reverse transcriptase, and integrase (1). The first step of replication is the binding of the glycoprotein to the receptor protein (2). Once these have been bound, the cell membrane degrades, becoming part of the host cell, and the RNA strands and enzymes enter the cell (3). Within the cell, reverse transcriptase creates a complementary strand of DNA from the retrovirus RNA and the RNA is degraded; this strand of DNA is known as cDNA (4). The cDNA is then replicated, and the two strands form a weak bond and enter the nucleus (5). Once in the nucleus, the DNA is integrated into the host cell's DNA with the help of integrase (6). This cell can either stay dormant, or RNA may be synthesized from the DNA and used to create the proteins for a new retrovirus (7). Ribosome units are used to transcribe the mRNA of the virus into the amino acid sequences which can be made into proteins in the rough endoplasmic reticulum. This step will also make viral enzymes and capsid proteins (8). Viral RNA will be made in the nucleus. These pieces are then gathered together and are pinched off of the cell membrane as a new retrovirus (9). Credit: Wikipedia/CC BY-SA 3.0
A retrovirus has a membrane containing glycoproteins, which are able to bind to a receptor protein on a host cell. There are two strands of RNA within the cell that have three enzymes: protease, reverse transcriptase, and integrase (1). The first step of replication is the binding of the glycoprotein to the receptor protein (2). Once these have been bound, the cell membrane degrades, becoming part of the host cell, and the RNA strands and enzymes enter the cell (3). Within the cell, reverse transcriptase creates a complementary strand of DNA from the retrovirus RNA and the RNA is degraded; this strand of DNA is known as cDNA (4). The cDNA is then replicated, and the two strands form a weak bond and enter the nucleus (5). Once in the nucleus, the DNA is integrated into the host cell's DNA with the help of integrase (6). This cell can either stay dormant, or RNA may be synthesized from the DNA and used to create the proteins for a new retrovirus (7). Ribosome units are used to transcribe the mRNA of the virus into the amino acid sequences which can be made into proteins in the rough endoplasmic reticulum. This step will also make viral enzymes and capsid proteins (8). Viral RNA will be made in the nucleus. These pieces are then gathered together and are pinched off of the cell membrane as a new retrovirus (9). Credit: Wikipedia/CC BY-SA 3.0
Antibody clinical trial sends HIV into hiding for months
Antibody clinical trial sends HIV into hiding for months

When Will There Ever Be a Cure for HIV?

Nanalyze
HIV cure: STDs could be treated using stem cell treatment | Daily Star
HIV cure: STDs could be treated using stem cell treatment | Daily Star

Ween is Keen at Fillmore Miami Beach

WPLG Local 10
Bone marrow extractions help make stem cell transplants possible. (Getty Images: Morsa Images)
Bone marrow extractions help make stem cell transplants possible. (Getty Images: Morsa Images)

Gene editing holds promise for shrinking HIV 'reservoir'

Fred Hutch News Service

CRISPR used to destroy the regulatory genes of HIV

Drug Target Review

Gene editing shows promise in combating HIV reservoirs

FierceBiotech

Gene Editing Blocks HIV Transmission In Cells

Asian Scientist Magazine

Can gene therapy be used to cure Aids?

Health24
In this Jan. 26, 2018 photo, Matt Chappell, right, is checked by Dr. Christopher Schiessl during an appointment at a medical center in San Francisco. For more than a decade, the strongest AIDS drugs could not fully control Chappell's HIV infection. Now his body does it by itself, thanks to the first gene editing experiments in people.
In this Jan. 26, 2018 photo, Matt Chappell, right, is checked by Dr. Christopher Schiessl during an appointment at a medical center in San Francisco. For more than a decade, the strongest AIDS drugs could not fully control Chappell's HIV infection. Now his body does it by itself, thanks to the first gene editing experiments in people.

Can gene therapy be harnessed to fight AIDS?

STAT

Genome editing method targets AIDS virus

Science Daily
A colored scanning electron micrograph of a white blood cell amid red blood cells. Researchers hope a new method to boost immune systems could make a treatment available to patients with almost any type of cancer.
A colored scanning electron micrograph of a white blood cell amid red blood cells. Researchers hope a new method to boost immune systems could make a treatment available to patients with almost any type of cancer.

Promising HIV treatment fails in human trials

Genetic Literacy Project

Genetically Modified T Cells Might Help Fight HIV

Scientific American

CRISPR used to block HIV virus replicating in cells

BioNews

This is how HIV decides to become active

Medical News Today

Why I injected myself with an untested gene therapy

BBC News

CRISPR Editing Stops HIV Virus in Infected Cells

Technology Networks

New way found to defeat HIV latency

Science Daily
Adam Carrico, Ph.D., associate professor of Public Health Sciences and Psychology at the University of Miami Miller School of Medicine. Credit: University of Miami Miller School of Medicine
Adam Carrico, Ph.D., associate professor of Public Health Sciences and Psychology at the University of Miami Miller School of Medicine. Credit: University of Miami Miller School of Medicine
Credit: CC0 Public Domain
Credit: CC0 Public Domain

HIV and CAR T-Cell Treatments

Healthline

Gene editing could cure HIV, end AIDS crisis

Guardian
Credit: CC0 Public Domain
Credit: CC0 Public Domain

Genome Editor CRISPR Targets AIDS Virus HIV

Geek

SA study reveals important link between genes and Aids

Times LIVE
Virus-like shells budding off from one neuron and moving to another.
Virus-like shells budding off from one neuron and moving to another.
Aaron Traywick
Aaron Traywick

Pathways to a cure for AIDS

Knowable Magazine

How HIV is shielded from immune attack

Science Daily

Why Gene Therapy Is No Longer a Pipe Dream

Pacific Standard

Influence of Vitamin D in HIV Infection

Infectious Disease Advisor
A blood clot, seen through a scanning electron microscope
A blood clot, seen through a scanning electron microscope

The Patients Who Don't Want to Be Cured

The Atlantic
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