Harnessing the Electron-Withdrawing Inductive Effect of One-Component Ionizable Amphiphilic Janus Dendrimers Unveils Cation−π Interactions and Their Important Roles to Targeted mRNA Delivery
By Juncheng Lu, Elena N Atochina-Vasserman & Virgil Percec
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses
By Christopher A Hunter, Colleen Furey & Mohamad-Gabriel Alameh
Toward a Complete Elucidation of the Primary Structure–Activity in Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers for In Vivo Delivery of Luc-mRNA
By Dipankar Sahoo, Elena N Atochina-Vasserman & Juncheng Lu
Monitoring mRNA vaccine antigen expression in vivo using PET/CT
By Mohamad-Gabriel Alameh, Houping Ni & Catherine Hou
Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers
By Jaclynn A Meshanni, Elena N Atochina-Vasserman & Drew Weissman
iDC-targeting PfCSP mRNA vaccine confers superior protection against Plasmodium compared to conventional mRNA
By Prakash Srinivasan, Yevel Flores & Sean Yanik
Publisher Correction: Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia
By Hannah C Safford, Mohamad-Gabriel Alameh & Ajay S Thatte
Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia
By Hannah C Safford, Hannah C Geisler & Emily Han
Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution
By Xuexiang Han, Lulu Xue & Claude C Warzecha
A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection
By Joseph P. Zackular, Mohamad-Gabriel Alameh & Marc Lavertu
Bivalent norovirus mRNA vaccine elicits cellular and humoral responses protecting human enteroids from GII.4 infection
By Lisa C Lindesmith, Elena N Atochina-Vasserman & Christiane Wobus
Broad protection and respiratory immunity of dual mRNA vaccination against SARS-CoV-2 variants | npj Vaccines
By Kenneth S Plante, Rachel A. Reyna & Renee Hajnik
mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies
By Gabriel Ozorowski, Wen-Hsin Lee & Richard T. Wyatt
Intramuscular immunization of unmodified OVA-LNP inhibits tumor growth...
By Mohamad-Gabriel Alameh, Drew Weissman & Tanapat Palaga
Evaluation of mRNA-LNP and adjuvanted protein SARS-CoV-2 vaccines in a maternal antibody mouse model
By Mohamad-Gabriel Alameh, Scott E Hensley & Drew Weissman
Transient growth factor expression via mRNA in lipid nanoparticles promotes hepatocyte cell therapy in mice
By Valerie Gouon-evans, Fatima Rizvi & Hiromi Muramatsu
Evaluation of the immunogenicity of an mRNA vectored Nipah virus vaccine candidate in pigs
By Miriam Pedrera, Glenn A Marsh & Dalan Bailey
High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models
By Lulu Xue, Xuexiang Han & Mohamad-Gabriel Alameh
In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors
By Xuexiang Han, Lulu Xue & Claude C Warzecha
Multivalent cytomegalovirus glycoprotein B nucleoside modified mRNA vaccines did not demonstrate a greater antibody breadth | npj Vaccines
By Sarah M Valencia, Norbert Pardi & Leike Li
Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination
By Drew Weissman, Justin J Taylor & Jin-Yi Tang
Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS
By Evelina Angov, Chris J. Janse & Drew Weissman
mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis
By Erol Fikrig, Geoffrey E Lynn & Norbert Pardi
2023 Nobel Prize in Medicine (mRNA vaccines)
By Katalin Karikó & Drew Weissman
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
By Elena N Atochina-Vasserman, Juncheng Lu & Virgil Percec
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
By Elena N Atochina-Vasserman, Juncheng Lu & Devendra S. Maurya
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines
By Mohamad-Gabriel Alameh, Majed Ghattas & Lulu Xue
A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria
By Mohamad-Gabriel Alameh, Hamidah Raduwan & Erol Fikrig
Immunogenicity and protective efficacy of SARS-CoV-2 mRNA vaccine encoding secreted non-stabilized spike in female mice
By Eakachai Prompetchara, Supranee Buranapraditkun & Mohamad-Gabriel Alameh
Hepatitis C virus E1 and modified E2 delivered from an mRNA vaccine induces protective immunity | npj Vaccines
By Ranjit Ray, Erin K. Reagan & Drew Weissman
Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals
By Kenneth M. Kim, Elias El Haddad & Michele A Kutzler
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
By Hannah C Safford, Ajay S Thatte & Marshall S Padilla
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer
By Mohamad-Gabriel Alameh, Norbert Pardi & Ryane Jilian
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
By Lulu Xue, Xuexiang Han & Mohamad-Gabriel Alameh
mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum | npj Vaccines
By Mohamad-Gabriel Alameh, Abhai K Tripathi & Fidel Zavala
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
By Colleen Furey, Norbert Pardi & Valerie Le Sage
Direct Delivery of mRNA-Loaded Lipid Nanoparticles to the Hematopoietic Stem Cell Niche
By Seul K Jung, Stefano Rivella & Peter Kurre
In Vivo Modification of Hematopoietic Stem Cells By Targeted Lipid Nanoparticles Encapsulating mRNA
By Tyler E. Papp, Hamideh Parhiz & Stefano Rivella
Safety and immunogenicity of a prefusion non-stabilized spike protein mRNA COVID-19 vaccine: a phase I trial
By Supranee Buranapraditkun, Kanitha Patarakul & Sivaporn Gatechompol
mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model
By Mohamad-Gabriel Alameh, Eakachai Prompetchara & Drew Weissman
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
By Xuexiang Han, Marshall S Padilla & Mohamad-Gabriel Alameh
An ionizable lipid toolbox for RNA delivery
By Hanwen Zhang, Xuexiang Han & Mohamad-Gabriel Alameh
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
By Elena N Atochina-Vasserman, Juncheng Lu & Virgil Percec
Nucleoside-modified mRNA vaccination partially overcomes maternal antibody inhibition of de novo immune responses in mice
By Norbert Pardi, Drew Weissman & Scott Hensley